Development and Evaluation of Mucoadhesive Buccal Patches for Rheumatoid Arthritis Treatment Using Lornoxicam Drug
1*
1 Associate Professor, RKDF College of Pharmacy, Sarvepalli Radhakrishnan University, Bhopal (MP)
* Corresponding Author
📄 Abstract
Abstract
Mucoadhesive buccal drug delivery is one of the novel drug delivery system. Buccal drug delivery is safer mode of drug delivery system as buccal mucosa has an excellent accessibility, which lead to direct access to circulation through the internal jugular vein bypass the drug from hepatic first pass effect and avoidance of pre-systemic elimination within the GIT. Some of the NSAID already have been formulated and evaluated as muccoadhesive buccal patches but most of them still been unexplored. Buccal formulation of NSAID is promising formulation of near future. A few NSAID like ketorolac, aceclofenac, diclofenac etc.have been incorporated in buccal dosage form. In the present study, mucoadhesive buccal patches of lornoxicam were prepared using different polymers. The patches were prepared by using solvent casting method. Amongst all the prepared formulations, HPMCK4m and cabopol (1:1) showed better drug release of 76% ± 1.83 after 24 hrs. By reviewing the result obtained, on the basis of the invitro characterization it was cocluded that lornoxicam can be administered through buccal route as a matrix type buccal drug delivery system. Development of lornoxicam muccoadhesive buccal drug delivery patches using HPMCK4m and carbopol increases patient compliance.
Copyright (c) 2026 UnivColl International Multidisciplinary Research Journal
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How to Cite
Gangre, S. (2026). Development and evaluation of mucoadhesive buccal patches for rheumatoid arthritis treatment using lornoxicam drug. UnivColl International Multidisciplinary Research Journal, 2(3), 1–8.
Indexing & Accreditations
References
- Khan, S., Nayarit, P., Kumar, S. P., After, A. M., & Husain, W. M. (2016). Novel approaches: Mucoadhesive buccal drug delivery system. International Journal of Research and Development in Pharmacy and Life Sciences, 5, 2201–2208.
- Mishra, S., Patel, P. L., Seaton, M. F., Jacobsen, J., & Rising, M. R. (Year). Development and in vitro/in vivo testing of mucoadhesive buccal patches releasing benzydamine and lidocaine. International Journal of Pharmaceutics, 1333, 1–7.
- Puratchikody, A., Prasanth, V. V., Mathew, S. T., & Kumar, B. A. (2011). Buccal drug delivery: Past, present and future—A review. International Journal of Drug Delivery, 3, 171–184.
- Acharya, A., Dhakal, P., & Khadka, D. (2016). Formulation and evaluation of transdermal gel of lornoxicam and its delivery by passive and iontophoresis method: A comparative study. International Journal of Pharmaceutical Sciences and Research, 7, 810–818.
- Parmar, G. H., Jain, J. J., Patel, K. T., & Patel, M. V. (2010). Buccal patches: A technical note. International Journal of Pharmaceutical Sciences Review and Research, 4, 178–182.
- Chopade, V. V., & Chaudhari, P. D. (2014). Development and validation of stability-indicating RP-HPLC assay method for determination of lornoxicam in SEDDS formulation. International Journal of Pharmaceutical Sciences and Research, 5, 2060–2065.
- Mishra, S., Kumar, P. G., & Kothiyal, P. (2012). Recent approaches in buccal patches: A review article. The Pharma Innovation, 7, 78–86.
- Jain, N., Bisht, L., Sharma, A., Pandey, R., Kumar, B., & Dhaka, M. (2024). A review: Mucoadhesive buccal patches. Research Journal of Pharmacy and Technology, 7(7).
- Katnauria, A., Abhishek, Choudhary, H., & Verma, K. (2024). Development and evaluation of mucoadhesive buccal patch of losartan potassium. Asian Journal of Pharmacy and Technology, 14(2), 157–162.
- Kumar, V. B., Ashoka, K., Sudheer, B., Suresh, K. K., Rao, S. V., Kirtinidhi, K., Patel, H., & Rajesh Kumar, P. (2011). Formulation design, in vitro evaluation and stability studies on mucoadhesive buccal film of anti-anginal calcium channel blocker. Journal of Applied Pharmaceutical Science, 6, 136–142.
- Biswas, G. R., Biswas, S., & Majee, S. B. (2014). Development and evaluation of buccal mucoadhesive patches of diclofenac potassium. International Journal of Pharmaceutical Sciences Review and Research, 2, 111–115.
- Rossi, C., Perioli, L., Ambrogi, V., Ricci, M., Giovagnoli, S., & Capuccella, M. (2004). Development of mucoadhesive patches for administration of ibuprofen. Journal of Controlled Release, 99, 73–82.
- Chandrasekar, R., & Chandrasekar, S. (2017). Natural herbal treatment for rheumatoid arthritis: A review. International Journal of Pharmaceutical Sciences and Research, 8, 368–384.
- El Sharawy, A. M., Shukr, M. H., & Elshafeey, A. H. (2017). Formulation and optimization of duloxetine hydrochloride buccal films: In vitro and in vivo evaluation. National Library of Medicine, 1762–1769.
- Cheng, H., Wang, T., Yanlong, F., Wu, F., Shen, L., & Lin, X. (2025). Characteristics, preparation and applicability of cellulose ether-based buccal films in oral delivery systems. Drug Delivery, 32(1), 1071–7544.
- El Sharawy, A. M., Shukr, M. H., & Elshafeey, A. H. (2017). Formulation and optimization of duloxetine hydrochloride buccal film: In vitro and in vivo study evaluation. Drug Delivery, 14(1), 1071–7544.
- Mao, L., Wu, W., Wang, M., Guo, J., Li, H., Zhang, S., Xu, J., & Zou, J. (2021). Targeted treatment for osteoarthritis: Drug and delivery system. Drug Delivery, 28(1), 1861–1876.
- Parmar, H. G., Jain, J. J., Patel, T. K., & Patel, V. M. (2020). Buccal patch: A note. International Journal of Pharmaceutical Sciences Review and Research, 4(3).
- Rajput, G., Majmudar, F., & Patel, J. (2023). Formulation and evaluation of mucoadhesive glipizide films. Acta Pharmaceutica, 61(16), 99–104.